| .ski | Generic | Identity Digital Limited | — | — |
| .skin | Generic | XYZ.COM LLC | — | — |
| .sky | Generic | Sky UK Limited | — | — |
| .skype | Generic | Microsoft Corporation | — | — |
| .sl | Country Code | Sierratel | 🇸🇱Sierra Leone | — |
| .sling | Generic | DISH Technologies L.L.C. | — | — |
| .sm | Country Code | Telecom Italia San Marino S.p.A. | 🇸🇲San Marino | — |
| .smart | Generic | Smart Communications, Inc. (SMART) | — | — |
| .smile | Generic | Amazon Registry Services, Inc. | — | — |
| .sn | Country Code | Universite Cheikh Anta Diop | 🇸🇳Senegal | — |
| .sncf | Generic | Société Nationale SNCF | — | — |
| .so | Country Code | Ministry of Post and Telecommunications | 🇸🇴Somalia | — |
| .soccer | Generic | Binky Moon, LLC | — | — |
| .social | Generic | Dog Beach, LLC | — | — |
| .softbank | Generic | SoftBank Group Corp. | — | — |
| .software | Generic | Dog Beach, LLC | — | — |
| .sohu | Generic | Sohu.com Limited | — | — |
| .solar | Generic | Binky Moon, LLC | — | — |
| .solutions | Generic | Binky Moon, LLC | — | — |
| .song | Generic | Amazon Registry Services, Inc. | — | — |
| .sony | Generic | Sony Corporation | — | — |
| .soy | Generic | Charleston Road Registry Inc. | — | — |
| .spa | Generic | Asia Spa and Wellness Promotion Council Limited | — | — |
| .space | Generic | Radix Technologies Inc. | — | — |
| .sport | Generic | SportAccord | — | — |
| .spot | Generic | Amazon Registry Services, Inc. | — | — |
| .sr | Country Code | Telesur | 🇸🇷Suriname | — |
| .srl | Generic | InterNetX Corp. | — | — |
| .ss | Country Code | National Communication Authority (NCA) | 🇸🇸South Sudan | — |
| .st | Country Code | Tecnisys | 🇸🇹Sao Tome and Principe | — |
| .stada | Generic | STADA Arzneimittel AG | — | — |
| .staples | Generic | Staples, Inc. | — | — |
| .star | Generic | Star India Private Limited | — | — |
| .statebank | Generic | STATE BANK OF INDIA | — | — |
| .statefarm | Generic | State Farm Mutual Automobile Insurance Company | — | — |
| .stc | Generic | Saudi Telecom Company | — | — |
| .stcgroup | Generic | Saudi Telecom Company | — | — |
| .stockholm | Generic | Stockholms kommun | — | — |
| .storage | Generic | XYZ.COM LLC | — | — |
| .store | Generic | Radix Technologies Inc. | — | — |
| .stream | Generic | dot Stream Limited | — | — |
| .studio | Generic | Dog Beach, LLC | — | — |
| .study | Generic | Registry Services, LLC | — | — |
| .style | Generic | Binky Moon, LLC | — | — |
| .su | Country Code | Russian Institute for Development of Public Networks (ROSNIIROS) | 🇸🇺Soviet Union (legacy) | — |
| .sucks | Generic | Vox Populi Registry Ltd. | — | — |
| .supplies | Generic | Binky Moon, LLC | — | — |
| .supply | Generic | Binky Moon, LLC | — | — |
| .support | Generic | Binky Moon, LLC | — | — |
| .surf | Generic | Registry Services, LLC | — | — |