| .sas | Generic | Research IP LLC | — | — |
| .save | Generic | Amazon Registry Services, Inc. | — | — |
| .saxo | Generic | Saxo Bank A/S | — | — |
| .sb | Country Code | Solomon Telekom Company Limited | 🇸🇧Solomon Islands | — |
| .sbi | Generic | STATE BANK OF INDIA | — | — |
| .sbs | Generic | Shortdot SA | — | — |
| .sc | Country Code | VCS Pty Ltd | 🇸🇨Seychelles | — |
| .scb | Generic | The Siam Commercial Bank Public Company Limited ("SCB") | — | — |
| .schaeffler | Generic | Schaeffler Technologies AG & Co. KG | — | — |
| .schmidt | Generic | SCHMIDT GROUPE S.A.S. | — | — |
| .scholarships | Generic | Scholarships.com, LLC | — | — |
| .school | Generic | Binky Moon, LLC | — | — |
| .schule | Generic | Binky Moon, LLC | — | — |
| .schwarz | Generic | Schwarz Domains und Services GmbH & Co. KG | — | — |
| .science | Generic | dot Science Limited | — | — |
| .scot | Generic | Dot Scot Registry Limited | — | — |
| .sd | Country Code | Sudan Internet Society | 🇸🇩Sudan | — |
| .se | Country Code | The Internet Infrastructure Foundation | 🇸🇪Sweden | — |
| .search | Generic | Charleston Road Registry Inc. | — | — |
| .seat | Generic | SEAT, S.A. (Sociedad Unipersonal) | — | — |
| .secure | Generic | Amazon Registry Services, Inc. | — | — |
| .security | Generic | XYZ.COM LLC | — | — |
| .seek | Generic | Seek Limited | — | — |
| .select | Generic | Registry Services, LLC | — | — |
| .sener | Generic | Sener Ingeniería y Sistemas, S.A. | — | — |
| .services | Generic | Binky Moon, LLC | — | — |
| .seven | Generic | Seven West Media Ltd | — | — |
| .sew | Generic | SEW-EURODRIVE GmbH & Co KG | — | — |
| .sex | Generic | ICM Registry SX LLC | — | — |
| .sexy | Generic | Internet Naming Co. | — | — |
| .sfr | Generic | Societe Francaise du Radiotelephone - SFR | — | — |
| .sg | Country Code | Singapore Network Information Centre (SGNIC) Pte Ltd | 🇸🇬Singapore | — |
| .sh | Country Code | Government of St. Helena | 🇸🇭Saint Helena | — |
| .shangrila | Generic | Shangri-La International Hotel Management Limited | — | — |
| .sharp | Generic | Sharp Corporation | — | — |
| .shell | Generic | Shell Information Technology International Inc | — | — |
| .shia | Generic | Emergency Back-End Registry Operator Program - ICANN | — | — |
| .shiksha | Generic | Identity Digital Limited | — | — |
| .shoes | Generic | Binky Moon, LLC | — | — |
| .shop | Generic | GMO Registry, Inc. | — | — |
| .shopping | Generic | Binky Moon, LLC | — | — |
| .shouji | Generic | Beijing Qihu Keji Co., Ltd. | — | — |
| .show | Generic | Binky Moon, LLC | — | — |
| .si | Country Code | Academic and Research Network of Slovenia (ARNES) | 🇸🇮Slovenia | — |
| .silk | Generic | Amazon Registry Services, Inc. | — | — |
| .sina | Generic | Sina Corporation | — | — |
| .singles | Generic | Binky Moon, LLC | — | — |
| .site | Generic | Radix Technologies Inc. SEZC | — | — |
| .sj | Country Code | Norid A/S | 🇸🇯Svalbard and Jan Mayen | — |
| .sk | Country Code | SK-NIC, a.s. | 🇸🇰Slovakia | — |