| .schmidt | SCHMIDT GROUPE S.A.S. | — |
| .scholarships | Scholarships.com, LLC | — |
| .school | Binky Moon, LLC | — |
| .schule | Binky Moon, LLC | — |
| .schwarz | Schwarz Domains und Services GmbH & Co. KG | — |
| .science | dot Science Limited | — |
| .scot | Dot Scot Registry Limited | — |
| .search | Charleston Road Registry Inc. | — |
| .seat | SEAT, S.A. (Sociedad Unipersonal) | — |
| .secure | Amazon Registry Services, Inc. | — |
| .security | XYZ.COM LLC | — |
| .seek | Seek Limited | — |
| .select | Registry Services, LLC | — |
| .sener | Sener Ingeniería y Sistemas, S.A. | — |
| .services | Binky Moon, LLC | — |
| .seven | Seven West Media Ltd | — |
| .sew | SEW-EURODRIVE GmbH & Co KG | — |
| .sex | ICM Registry SX LLC | — |
| .sexy | Internet Naming Co. | — |
| .sfr | Societe Francaise du Radiotelephone - SFR | — |
| .shangrila | Shangri-La International Hotel Management Limited | — |
| .sharp | Sharp Corporation | — |
| .shell | Shell Information Technology International Inc | — |
| .shia | Emergency Back-End Registry Operator Program - ICANN | — |
| .shiksha | Identity Digital Limited | — |
| .shoes | Binky Moon, LLC | — |
| .shop | GMO Registry, Inc. | — |
| .shopping | Binky Moon, LLC | — |
| .shouji | Beijing Qihu Keji Co., Ltd. | — |
| .show | Binky Moon, LLC | — |
| .silk | Amazon Registry Services, Inc. | — |
| .sina | Sina Corporation | — |
| .singles | Binky Moon, LLC | — |
| .site | Radix Technologies Inc. SEZC | — |
| .ski | Identity Digital Limited | — |
| .skin | XYZ.COM LLC | — |
| .sky | Sky UK Limited | — |
| .skype | Microsoft Corporation | — |
| .sling | DISH Technologies L.L.C. | — |
| .smart | Smart Communications, Inc. (SMART) | — |
| .smile | Amazon Registry Services, Inc. | — |
| .sncf | Société Nationale SNCF | — |
| .soccer | Binky Moon, LLC | — |
| .social | Dog Beach, LLC | — |
| .softbank | SoftBank Group Corp. | — |
| .software | Dog Beach, LLC | — |
| .sohu | Sohu.com Limited | — |
| .solar | Binky Moon, LLC | — |
| .solutions | Binky Moon, LLC | — |
| .song | Amazon Registry Services, Inc. | — |