| .schmidt | Generic | SCHMIDT GROUPE S.A.S. | — | — |
| .scholarships | Generic | Scholarships.com, LLC | — | — |
| .school | Generic | Binky Moon, LLC | — | — |
| .schule | Generic | Binky Moon, LLC | — | — |
| .schwarz | Generic | Schwarz Domains und Services GmbH & Co. KG | — | — |
| .science | Generic | dot Science Limited | — | — |
| .scot | Generic | Dot Scot Registry Limited | — | — |
| .search | Generic | Charleston Road Registry Inc. | — | — |
| .seat | Generic | SEAT, S.A. (Sociedad Unipersonal) | — | — |
| .secure | Generic | Amazon Registry Services, Inc. | — | — |
| .security | Generic | XYZ.COM LLC | — | — |
| .seek | Generic | Seek Limited | — | — |
| .select | Generic | Registry Services, LLC | — | — |
| .sener | Generic | Sener Ingeniería y Sistemas, S.A. | — | — |
| .services | Generic | Binky Moon, LLC | — | — |
| .seven | Generic | Seven West Media Ltd | — | — |
| .sew | Generic | SEW-EURODRIVE GmbH & Co KG | — | — |
| .sex | Generic | ICM Registry SX LLC | — | — |
| .sexy | Generic | Internet Naming Co. | — | — |
| .sfr | Generic | Societe Francaise du Radiotelephone - SFR | — | — |
| .shangrila | Generic | Shangri-La International Hotel Management Limited | — | — |
| .sharp | Generic | Sharp Corporation | — | — |
| .shell | Generic | Shell Information Technology International Inc | — | — |
| .shia | Generic | Emergency Back-End Registry Operator Program - ICANN | — | — |
| .shiksha | Generic | Identity Digital Limited | — | — |
| .shoes | Generic | Binky Moon, LLC | — | — |
| .shop | Generic | GMO Registry, Inc. | — | — |
| .shopping | Generic | Binky Moon, LLC | — | — |
| .shouji | Generic | Beijing Qihu Keji Co., Ltd. | — | — |
| .show | Generic | Binky Moon, LLC | — | — |
| .silk | Generic | Amazon Registry Services, Inc. | — | — |
| .sina | Generic | Sina Corporation | — | — |
| .singles | Generic | Binky Moon, LLC | — | — |
| .site | Generic | Radix Technologies Inc. SEZC | — | — |
| .ski | Generic | Identity Digital Limited | — | — |
| .skin | Generic | XYZ.COM LLC | — | — |
| .sky | Generic | Sky UK Limited | — | — |
| .skype | Generic | Microsoft Corporation | — | — |
| .sling | Generic | DISH Technologies L.L.C. | — | — |
| .smart | Generic | Smart Communications, Inc. (SMART) | — | — |
| .smile | Generic | Amazon Registry Services, Inc. | — | — |
| .sncf | Generic | Société Nationale SNCF | — | — |
| .soccer | Generic | Binky Moon, LLC | — | — |
| .social | Generic | Dog Beach, LLC | — | — |
| .softbank | Generic | SoftBank Group Corp. | — | — |
| .software | Generic | Dog Beach, LLC | — | — |
| .sohu | Generic | Sohu.com Limited | — | — |
| .solar | Generic | Binky Moon, LLC | — | — |
| .solutions | Generic | Binky Moon, LLC | — | — |
| .song | Generic | Amazon Registry Services, Inc. | — | — |